When it comes to treating allergies, two names often come to mind: Benadryl (diphenhydramine) and Claritin (loratadine). Both are antihistamines, but they belong to different generations and have varying characteristics. This article will explore whether these two can be taken together, the potential risks, and recommended precautions.

Understanding the Basics

  1. Benadryl (diphenhydramine): A first-generation antihistamine, Benadryl is commonly used to treat symptoms of allergies and the common cold. It’s known for its fast action but can cause drowsiness.
  2. Claritin (loratadine): A second-generation antihistamine, Claritin is designed to relieve allergy symptoms without causing drowsiness, making it more suitable for daytime use.

Can They Be Taken Together?

Theoretically, Benadryl and Claritin can be taken together because they work in slightly different ways and are metabolized differently in the body. However, before doing so, it’s important to consider several factors:

  1. Purpose: If one drug isn’t managing your symptoms, combining them might offer more comprehensive relief. For example, if you’re traveling and need quick relief from an allergic reaction, Benadryl can act quickly, while Claritin offers longer-lasting relief without sedation.
  2. Side Effects: While Claritin is non-drowsy, combining it with Benadryl could enhance Benadryl’s sedative effects. This might be problematic if you’re driving, operating machinery, or performing tasks requiring mental alertness.
  3. Health Conditions: Having certain health issues, like glaucoma or severe high blood pressure, might preclude you from combining these medications.
  4. Other Medications: If you’re on other medications, combining them with both Benadryl and Claritin could lead to drug interactions.

Always consult with a healthcare provider before combining any medications.

Risks of Combining Benadryl and Claritin

  1. Enhanced Sedation: The drowsiness from Benadryl can be amplified, even with non-sedative Claritin.
  2. Anticholinergic Load: Both drugs have anticholinergic effects, which could increase the risk of side effects like dry mouth, constipation, and urinary retention.
  3. Potential Overdose: Overdosing on antihistamines can lead to severe health issues, including heart problems.

Recommended Precautions

  1. Start with One: Before combining, ensure that one medication alone isn’t sufficient for symptom relief.
  2. Monitor Your Body: Keep track of any new or intensified side effects.
  3. Limit Alcohol: Alcohol can enhance the sedative effects of these drugs.
  4. Consult a Healthcare Professional: Always check with a pharmacist or doctor when considering taking multiple medications simultaneously.


  1. Why might someone consider taking both?
    They might need quick relief (Benadryl) and also long-lasting, non-drowsy relief (Claritin) from allergy symptoms.
  2. Are there alternatives to combining these medications?
    Yes. There are other antihistamines and treatments for allergies. Always discuss alternatives with a healthcare provider.
  3. How long should I wait between taking Benadryl and Claritin?
    If you feel the need to take both, space them out. For instance, take Claritin in the morning and Benadryl at night.
  4. Can children take both?
    Always consult a pediatrician before giving any medication or combination of medications to a child.


While Benadryl and Claritin can technically be taken together, doing so requires careful consideration. Weighing the benefits against potential risks and always consulting with a healthcare professional is paramount. Individual needs and health profiles vary, so personalized advice is essential.