Physical Dependence on Tramadol

 Drug and Alcohol Dependence demonstrates that tramadol potentially affects the GABA system within the brain, a neurochemical pathway that, when stimulated, decreases neuron activity by decreasing production of dopamine and other neurotransmitters. This technique is usually implicated in drug abuse and addiction, and it’s considered to be one among the potential mechanisms of addiction.

Physical dependence has also been shown through the WHO study, which indicates that, while some studies show only mild effects of dependence on the drug, others have shown a robust tendency toward physical and mental dependence which will cause addiction to tramadol. Again, prior history of drug abuse often contributes to cases during which tramadol addiction is present.

Physical and Mental Effects

Tramadol’s physical and mental effects are almost like those of other prescription painkillers, including, as reported by Healthline:

Nausea, vomiting, and indigestion

Slow breathing and heart rates

Confusion and inability to concentrate or focus

Depression and anxiety

Increased risk-taking behaviors and lowered inhibitions

Physical effects from injecting the drug, if applicable

These effects can become extremely uncomfortable, particularly if the individual overdoses on the drug. An overdose can cause extremely slow breathing which will end in the person passing out, becoming unresponsive, and experiencing coma or death.

Withdrawal Symptoms

According to The People’s Pharmacy, withdrawal from tramadol may result in a particularly uncomfortable withdrawal syndrome, sometimes mentioned as a discontinuation syndrome. Symptoms that arise upon stopping tramadol use may include:








Flulike symptoms


These symptoms are reported to be extremely uncomfortable and disturbing. However, because tramadol over night is taken into account to be safe, some medical professionals don’t offer a sound regimen for truly fizzling out the drug or advice on otherwise completing a secure detox that minimizes symptoms.

More on Withdrawal & Timelines







Support for Detox

Substance abuse treatment professionals in reputable drug rehab programs can provide experienced support for detox from tramadol. These professionals understand the challenges of detox from addictive substances and are ready to provide the medical support required to attenuate symptoms of withdrawal.

This support can include pharmacological treatments that assist in reducing the sensations described above. The opposite advantage of those programs is the ability to start drug abuse treatment and therapies which will help the individual learn to manage cravings and start to get over addiction to tramadol.

Tramadol Addiction

As with many substances that are abused for recreational reasons, research-based treatment programs provide therapies and other support which will help the individual learn to acknowledge triggers for cravings that cause abuse. This makes it possible for the individual to substitute other behaviors, reducing the likelihood of relapse to tramadol abuse.

Therapies include:

Cognitive Behavioral Therapy

Motivational Interviewing

Family and social therapy

Peer support engagement

Experiential therapy to manage mental conditions that contribute to addiction

Exercise, nutrition, and other supportive treatments