Rosuvastatin, commonly marketed under the brand name Crestor, is a medication that belongs to the statin class of drugs. It’s primarily prescribed to lower cholesterol and triglyceride levels, thereby reducing the risk of cardiovascular diseases such as heart attack and stroke. While the drug is effective for its intended purposes, like any medication, it comes with a list of potential side effects. This article delves into the long-term side effects of rosuvastatin to provide a clear understanding of what you may encounter during extended use.

Understanding the Role of Rosuvastatin

Before diving into the side effects, it’s essential to understand how rosuvastatin works. It inhibits the enzyme HMG-CoA reductase, which plays a critical role in cholesterol production in the liver. By lowering levels of LDL (“bad” cholesterol) and raising HDL (“good” cholesterol), the drug helps prevent atherosclerosis and other cardiovascular issues.

Common Long-Term Side Effects

Muscle Issues

One of the most common long-term side effects includes muscle pain or weakness, sometimes leading to a serious condition called rhabdomyolysis.

Liver Function

Long-term use can lead to elevated liver enzymes, requiring regular liver function tests to monitor any potential issues.


Statins like rosuvastatin have been associated with a slight increase in blood sugar levels, potentially contributing to the onset of type 2 diabetes.

Cognitive Function

Though rare, some people have reported memory loss or confusion while on long-term rosuvastatin therapy.

Less Common but Serious Side Effects

Kidney Issues

While infrequent, the medication can lead to kidney problems, often connected to the muscle issues that statins can cause.

Increased Stroke Risks

Some research suggests that long-term statin use might be linked to a specific type of stroke, although the data is not conclusive.

Who is at Greater Risk?

Some people are more susceptible to the long-term side effects of rosuvastatin:

  • Older adults
  • Individuals with liver or kidney disease
  • Those who drink excessive amounts of alcohol
  • Patients taking multiple medications

Monitoring and Mitigation

Regular check-ups and lab tests are essential for those on long-term rosuvastatin treatment. Lifestyle changes, such as diet and exercise, can also help mitigate the risks.


1. Can the long-term side effects be reversed?

Most side effects are reversible upon discontinuation of the medication, but it’s crucial to consult with your healthcare provider for tailored advice.

2. Is it safe to stop rosuvastatin suddenly?

It’s not advisable to stop any medication without consulting your healthcare provider, as this could have adverse effects on your condition.

3. Are there any alternatives to rosuvastatin?

There are other statins and cholesterol-lowering medications available, but the best choice depends on individual health conditions.

4. How often should I get checked when on long-term rosuvastatin?

A typical monitoring schedule includes liver function tests every 6 months, but your healthcare provider may recommend a different routine.


While rosuvastatin serves a critical function in lowering cholesterol and reducing cardiovascular risks, awareness of its long-term side effects is essential for comprehensive health management. Regular monitoring and prompt attention to side effects can go a long way in ensuring that the benefits of the medication outweigh the risks.