Lexapro, generically known as escitalopram, is a commonly prescribed antidepressant utilized to treat depression and generalized anxiety disorder. It falls under the selective serotonin reuptake inhibitor (SSRI) class. A common query among patients taking Lexapro revolves around its interaction with alcohol. Specifically, many wonder if they can skip a dose of Lexapro in order to consume alcohol. This article seeks to answer this question and provide clarity on the matter.

Understanding Lexapro’s Mechanism

Before diving into the central query, it’s essential to grasp how Lexapro functions. Lexapro increases serotonin levels in the brain, a neurotransmitter related to mood, sleep, and other essential functions. This augmentation aids in elevating mood and reducing symptoms of depression and anxiety.

Alcohol and Lexapro: The Interaction

Alcohol, on its own, has depressive effects on the central nervous system. When mixed with Lexapro:

  1. Increased Drowsiness: Both alcohol and Lexapro can cause drowsiness. When combined, this effect is often amplified.
  2. Decreased Efficacy of Lexapro: Consuming alcohol might hinder Lexapro’s effectiveness in treating depression or anxiety.
  3. Potential Overconsumption: Due to the amplified drowsiness, individuals might find it challenging to gauge their alcohol tolerance, leading to overconsumption.

Skipping a Dose: Is it Safe?

The idea of skipping a dose to consume alcohol assumes that this action will prevent the above interactions. However, this assumption might be misleading:

  1. Medication Half-life: Lexapro has a half-life of about 27 to 32 hours. This means even if you skip a dose, substantial amounts of the medication remain in your system, and interactions can still occur.
  2. Disruption in Treatment: Skipping a dose can lead to a disruption in the drug’s benefits and potentially exacerbate depression or anxiety symptoms.
  3. Withdrawal Symptoms: Suddenly stopping SSRI medications can lead to withdrawal symptoms, which might include dizziness, irritability, and nausea.


  1. Consultation is Key: If you are contemplating consuming alcohol while on Lexapro, always consult with a healthcare professional. They can provide personalized advice tailored to your specific circumstances.
  2. Moderation: If you do choose to drink, do so in moderation. This means limiting the number of drinks and understanding how alcohol affects you in conjunction with your medication.
  3. Stay Informed: Being well-informed about potential interactions and side effects can aid in making wise decisions about alcohol consumption.


  • Q: How long does Lexapro stay in the system?
    • A: Lexapro has a half-life of 27-32 hours, meaning it takes this duration for half of the drug to be eliminated from your system. Complete elimination takes several days.
  • Q: What are other common side effects of Lexapro?
    • A: Some side effects include drowsiness, dizziness, sleep problems, nausea, and dry mouth. Always consult a medical professional for a complete list and guidance.
  • Q: Can I ever drink alcohol while on Lexapro?
    • A: It’s not recommended, but if you do choose to drink, do so in moderation and always consult with a healthcare professional first.


While the allure of social drinking might seem tempting, especially during occasions or gatherings, it’s essential to prioritize health and well-being. The interactions between Lexapro and alcohol can be unpredictable and, at times, adverse. It’s always recommended to consult with a healthcare provider when considering mixing any medication with alcohol.