Cyclobenzaprine and ibuprofen are commonly prescribed medications that serve different but complementary roles in managing various health conditions. But can they be taken together? The short answer is yes, but as with any combined drug regimen, caution is required to ensure safe and effective use.

What is Cyclobenzaprine?

Cyclobenzaprine is a muscle relaxant, often used to alleviate symptoms of muscle spasms caused by conditions like acute musculoskeletal conditions or certain neurological disorders. It acts in the central nervous system to provide relief from discomfort and pain associated with muscle injuries and strains. Cyclobenzaprine is typically prescribed as part of a comprehensive treatment plan that may also include rest, physical therapy, and other medications.

What is Ibuprofen?

Ibuprofen, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) that is widely used to relieve pain, reduce inflammation, and lower fever. It’s a common choice for treating a wide range of conditions, from minor aches and pains to chronic conditions like arthritis. Ibuprofen works by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain.

Can Cyclobenzaprine and Ibuprofen Be Taken Together?

Yes, cyclobenzaprine and ibuprofen can generally be taken together. They work on different pathways and mechanisms in the body, so they do not directly interact with each other in a way that would render them unsafe or ineffective when combined. In fact, they can work synergistically—cyclobenzaprine alleviates muscle spasm and related discomfort, while ibuprofen addresses pain and inflammation.

This combination is often beneficial for people suffering from conditions like acute back or neck pain, where both muscle spasm and inflammation contribute to discomfort. In these cases, using these two medications together can enhance symptom relief more effectively than using either medication alone.

Safety and Considerations

Despite their compatibility, there are a few points to bear in mind when taking these medications together.

  1. Side Effects: Both drugs have potential side effects. Cyclobenzaprine can cause drowsiness, dry mouth, and dizziness, among other things. Ibuprofen can cause gastrointestinal upset, heartburn, and in rare cases, kidney or liver problems. Taking these medications together could potentially amplify these side effects.
  2. Dosage and Timing: It’s essential to follow your healthcare provider’s instructions regarding the dosage and timing of each medication. Never exceed the recommended dosage unless advised by a healthcare professional.
  3. Underlying Health Conditions: People with certain health conditions, like kidney disease, heart disease, or stomach ulcers, need to be cautious when taking these medications, especially ibuprofen. Similarly, the elderly or those taking other CNS depressants should use cyclobenzaprine with caution.
  4. Allergies: As with any medication, make sure you’re not allergic to either cyclobenzaprine or ibuprofen before taking them.


While it’s generally safe to take cyclobenzaprine and ibuprofen together, it should be under the guidance of a healthcare provider. They can help you navigate potential side effects, consider your overall health status, and provide personalized advice for your specific situation. Always remember that although these medications can provide relief, they are most effective when combined with other treatment strategies, like physical therapy and lifestyle changes, to address the root cause of your symptoms.